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In this blend of the B movie classic The Blob (1958), and some Romero's zombies film, a meteorite collides in a small town. Grant finds it, and is infected by a parasite worm, which installs in his brain and causes him a creepy transformation into a monster. Starla, his wife, and Bill, a policeman, will try to stop him and the plague of worms generated by the creature.
The problem with making a smart horror parody -- and James Gunn's Slither is a smart horror parody -- is that it's kind of like doing a virtuoso performance of 'My Way.' The skill of execution tends to be eclipsed by the tedium of the material.